Interferon-stimulated genes: roles in viral pathogenesis.
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ABSTRACT:
SUBMITTER: Schoggins JW
PROVIDER: S-EPMC4077717 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Interferon-stimulated genes: roles in viral pathogenesis.
Current opinion in virology 20140405
Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo. ...[more]
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