A novel RNA pentaloop fold involved in targeting ADAR2.
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ABSTRACT:
SUBMITTER: Stefl R
PROVIDER: S-EPMC1370747 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Publications
A novel RNA pentaloop fold involved in targeting ADAR2.
Stefl Richard R Allain Frédéric H-T FH
RNA (New York, N.Y.) 20050501 5
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The struct ...[more]
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