Ontology highlight
ABSTRACT:
SUBMITTER: Nagaswamy U
PROVIDER: S-EPMC97551 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Nagaswamy U U Gao X X Martinis S A SA Fox G E GE
Nucleic acids research 20011201 24
The structure of a 23 nt RNA sequence, rGGACCCGGGCUCAACCUGGGUCC, was elucidated using homonuclear NMR, distance geometry and restrained molecular dynamics. This RNA is analogous to residues 612-628 of the Escherichia coli 16S rRNA. The structure of the RNA reveals the presence of a pentaloop closed by a duplex stem in typical A-form conformation. The loop does not form a U-turn motif, as previously predicted. A non-planar A.C.A triple base interaction (hydrogen bonds A13 NH6-C10 O2 and C10 N3-A1 ...[more]