Ontology highlight
ABSTRACT:
SUBMITTER: Weil JE
PROVIDER: S-EPMC1370890 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Weil Jason E JE Beemon Karen L KL
RNA (New York, N.Y.) 20051121 1
Eukaryotic cells target mRNAs to the nonsense-mediated mRNA decay (NMD) pathway when translation terminates within the coding region. In mammalian cells, this is presumably due to a downstream signal deposited during pre-mRNA splicing. In contrast, unspliced retroviral RNA undergoes NMD in chicken cells when premature termination codons (PTCs) are present in the gag gene. Surprisingly, deletion of a 401-nt 3' UTR sequence immediately downstream of the normal gag termination codon caused this ter ...[more]