Ontology highlight
ABSTRACT:
SUBMITTER: Deutschbauer AM
PROVIDER: S-EPMC137751 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Deutschbauer Adam M AM Williams Roy M RM Chu Angela M AM Davis Ronald W RW
Proceedings of the National Academy of Sciences of the United States of America 20021113 24
We have quantitatively monitored the sporulation and germination efficiencies of approximately 4,200 yeast deletion strains in parallel by using a molecular bar coding strategy. In a single study, we doubled the number of genes functionally implicated in sporulation to approximately 400, identifying both positive and negative regulators. Our set of 261 sporulation-deficient genes illustrates the importance of autophagy, carbon utilization, and transcriptional machinery during sporulation. These ...[more]