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Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease.


ABSTRACT: To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate that HCV spread outpaces the T cell response and that HCV rapidly induces but is not controlled by IFN-alphabeta; that viral clearance follows the entry and accumulation of HCV-specific IFN-gamma-producing T cells in the liver; and that it may not require the destruction of infected cells.

SUBMITTER: Thimme R 

PROVIDER: S-EPMC137773 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature

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Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease.

Thimme Robert R   Bukh Jens J   Spangenberg Hans Christian HC   Wieland Stefan S   Pemberton Janell J   Steiger Carola C   Govindarajan Sugantha S   Purcell Robert H RH   Chisari Francis V FV  

Proceedings of the National Academy of Sciences of the United States of America 20021119 24


To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate t  ...[more]

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