Ontology highlight
ABSTRACT:
SUBMITTER: Thimme R
PROVIDER: S-EPMC137773 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Thimme Robert R Bukh Jens J Spangenberg Hans Christian HC Wieland Stefan S Pemberton Janell J Steiger Carola C Govindarajan Sugantha S Purcell Robert H RH Chisari Francis V FV
Proceedings of the National Academy of Sciences of the United States of America 20021119 24
To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate t ...[more]