Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC4035934 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kim Seong-Jun SJ Syed Gulam H GH Khan Mohsin M Chiu Wei-Wei WW Sohail Muhammad A MA Gish Robert G RG Siddiqui Aleem A
Proceedings of the National Academy of Sciences of the United States of America 20140414 17
Mitochondrial dynamics is crucial for the regulation of cell homeostasis. Our recent findings suggest that hepatitis C virus (HCV) promotes Parkin-mediated elimination of damaged mitochondria (mitophagy). Here we show that HCV perturbs mitochondrial dynamics by promoting mitochondrial fission followed by mitophagy, which attenuates HCV-induced apoptosis. HCV infection stimulated expression of dynamin-related protein 1 (Drp1) and its mitochondrial receptor, mitochondrial fission factor. HCV furth ...[more]