Disrupted synaptic development in the hypoxic newborn brain.
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ABSTRACT:
SUBMITTER: Curristin SM
PROVIDER: S-EPMC137784 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Publications
Disrupted synaptic development in the hypoxic newborn brain.
Curristin Sheila M SM Cao Anjun A Stewart William B WB Zhang Heping H Madri Joseph A JA Morrow Jon S JS Ment Laura R LR
Proceedings of the National Academy of Sciences of the United States of America 20021115 24
Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is accurately modeled in mice subjected to sublethal postnatal hypoxia. Massively parallel transcriptome analysis using cDNA microchips (9,262 genes), combined with immunohistochemical and protein assays, reveals that sublethal hypoxia accentuates genes subserving presynaptic function, and it suppresses genes involved with synaptic maturation, ...[more]
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