Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
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ABSTRACT:
SUBMITTER: Pohlkamp T
PROVIDER: S-EPMC4331535 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
Pohlkamp Theresa T Durakoglugil Murat M Lane-Donovan Courtney C Xian Xunde X Johnson Eric B EB Hammer Robert E RE Herz Joachim J
PloS one 20150217 2
Apolipoprotein E (ApoE) genotype is the strongest predictor of Alzheimer's Disease (AD) risk. ApoE is a cholesterol transport protein that binds to members of the Low-Density Lipoprotein (LDL) Receptor family, which includes LDL Receptor Related Protein 4 (Lrp4). Lrp4, together with one of its ligands Agrin and its co-receptors Muscle Specific Kinase (MuSK) and Amyloid Precursor Protein (APP), regulates neuromuscular junction (NMJ) formation. All four proteins are also expressed in the adult bra ...[more]
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