Ontology highlight
ABSTRACT:
SUBMITTER: Peng Q
PROVIDER: S-EPMC1378107 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Peng Qian Q Pevzner Pavel A PA Tesler Glenn G
PLoS computational biology 20060224 2
For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome. In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative "fragile breakage" model of chromosome evolution. In 2004, Sankoff and Trinh argued against the fragile breakage model and raised doubts that Pevzner and Tesler provided any evidence of rearrangement hot spots. We investigate whethe ...[more]