Ontology highlight
ABSTRACT:
SUBMITTER: Arlt MF
PROVIDER: S-EPMC2896008 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Arlt Martin F MF Glover Thomas W TW
DNA repair 20100421 6
Common fragile sites are loci that preferentially form gaps and breaks on metaphase chromosomes when DNA synthesis is perturbed, particularly after treatment with the DNA polymerase inhibitor, aphidicolin. We and others have identified several cell cycle checkpoint and DNA repair proteins that influence common fragile site stability. However, the initial events underlying fragile site breakage remain poorly understood. We demonstrate here that aphidicolin-induced gaps and breaks at fragile sites ...[more]