Ontology highlight
ABSTRACT:
SUBMITTER: Kortemme T
PROVIDER: S-EPMC137846 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
Kortemme Tanja T Baker David D
Proceedings of the National Academy of Sciences of the United States of America 20021015 22
Protein-protein recognition plays a central role in most biological processes. Although the structures of many protein-protein complexes have been solved in molecular detail, general rules describing affinity and selectivity of protein-protein interactions do not accurately account for the extremely diverse nature of the interfaces. We investigate the extent to which a simple physical model can account for the wide range of experimentally measured free energy changes brought about by alanine mut ...[more]