Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.
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ABSTRACT:
SUBMITTER: Hinrichs AL
PROVIDER: S-EPMC1380207 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
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Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.
Hinrichs Anthony L AL Wang Jen C JC Bufe Bernd B Kwon Jennifer M JM Budde John J Allen Rebecca R Bertelsen Sarah S Evans Whitney W Dick Danielle D Rice John J Foroud Tatiana T Nurnberger John J Tischfield Jay A JA Kuperman Samuel S Crowe Raymond R Hesselbrock Victor V Schuckit Marc M Almasy Laura L Porjesz Bernice B Edenberg Howard J HJ Begleiter Henri H Meyerhof Wolfgang W Bierut Laura J LJ Goate Alison M AM
American journal of human genetics 20051121 1
A coding single-nucleotide polymorphism (cSNP), K172N, in hTAS2R16, a gene encoding a taste receptor for bitter beta -glucopyranosides, shows significant association with alcohol dependence (P = .00018). This gene is located on chromosome 7q in a region reported elsewhere to exhibit linkage with alcohol dependence. The SNP is located in the putative ligand-binding domain and is associated with an increased sensitivity to many bitter beta -glucopyranosides in the presence of the N172 allele. Indi ...[more]
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