Ontology highlight
ABSTRACT:
SUBMITTER: Goardon N
PROVIDER: S-EPMC1383517 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Goardon Nicolas N Lambert Julie A JA Rodriguez Patrick P Nissaire Philippe P Herblot Sabine S Thibault Pierre P Dumenil Dominique D Strouboulis John J Romeo Paul-Henri PH Hoang Trang T
The EMBO journal 20060112 2
The passage from proliferation to terminal differentiation is critical for normal development and is often perturbed in malignancies. To define the molecular mechanisms that govern this process during erythropoiesis, we have used tagging/proteomics approaches and characterized protein complexes nucleated by TAL-1/SCL, a basic helix-loop-helix transcription factor that specifies the erythrocytic lineage. In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2 and Ldb1, we identify the ETO2 re ...[more]