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Growth factors involve in cellular proliferation, differentiation and migration during prostate cancer metastasis.

ABSTRACT: Growth factors play active role in cells proliferation, embryonic development regulation and cellular differentiation. Altered level growth factors promote malignant transformation of normal cells. There has been significant progress made in form of drugs, inhibitors and monoclonal antibodies against altered growth factor to treat the malignant form of cancer. Moreover, these altered growth factors in prostate cancer increases steroidal hormone levels, which promotes progression. Though this review we are highlighting the majorly involved growth factors in prostate carcinogenesis, this will enable to better design the therapeutic strategies to inhibit prostate cancer progression.

SUBMITTER: Isali I

PROVIDER: S-EPMC7133721 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Growth factors involve in cellular proliferation, differentiation and migration during prostate cancer metastasis.

Isali Ilaha I Al-Sadawi Mohammed Adel Ali MAA Qureshi Arshna A Khalifa Ahmad O AO Agrawal Mukesh K MK Shukla Sanjeev S

International journal of cell biology and physiology 20191007 1-2

Growth factors play active role in cells proliferation, embryonic development regulation and cellular differentiation. Altered level growth factors promote malignant transformation of normal cells. There has been significant progress made in form of drugs, inhibitors and monoclonal antibodies against altered growth factor to treat the malignant form of cancer. Moreover, these altered growth factors in prostate cancer increases steroidal hormone levels, which promotes progression. Though this rev ...[more]

PMID: 32259163

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