Ontology highlight
ABSTRACT:
SUBMITTER: Brown VM
PROVIDER: S-EPMC1383741 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Brown Vanessa M VM Ossadtchi Alex A Khan Arshad H AH Yee Simon S Lacan Goran G Melega William P WP Cherry Simon R SR Leahy Richard M RM Smith Desmond J DJ
Genome research 20020601 6
To facilitate high-throughput 3D imaging of brain gene expression, a new method called voxelation has been developed. Spatially registered voxels (cubes) are analyzed, resulting in multiple volumetric maps of gene expression analogous to the images reconstructed in biomedical imaging systems. Using microarrays, 40 voxel images for 9000 genes were acquired from brains of both normal mice and mice in which a pharmacological model of Parkinson's disease (PD) had been induced by methamphetamine. Qua ...[more]