Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease.
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ABSTRACT:
SUBMITTER: Knizewski L
PROVIDER: S-EPMC1395385 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease.
Knizewski Lukasz L Kinch Lisa L Grishin Nick V NV Rychlewski Leszek L Ginalski Krzysztof K
Journal of virology 20060301 5
Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle. ...[more]
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