Ontology highlight
ABSTRACT:
SUBMITTER: Temme C
PROVIDER: S-EPMC2659192 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Temme Claudia C Weissbach Rebekka R Lilie Hauke H Wilson Clive C Meinhart Anton A Meyer Sylke S Golbik Ralph R Schierhorn Angelika A Wahle Elmar E
The Journal of biological chemistry 20090107 13
Endonuclease G (EndoG) is a mitochondrial enzyme believed to be released during apoptosis to participate in the degradation of nuclear DNA. This paper describes a Drosophila protein, EndoGI, which inhibits EndoG specifically. EndoG and EndoGI associate with subpicomolar affinity, forming a 2:1 complex in which dimeric EndoG is bound by two tandemly repeated homologous domains of monomeric EndoGI. Binding appears to involve the active site of EndoG. EndoGI is present in the cell nucleus at microm ...[more]