Ontology highlight
ABSTRACT:
SUBMITTER: McCarty OJ
PROVIDER: S-EPMC1395485 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
McCarty Owen J T OJ Larson Mark K MK Auger Jocelyn M JM Kalia Neena N Atkinson Ben T BT Pearce Andrew C AC Ruf Sandra S Henderson Robert B RB Tybulewicz Victor L J VL Machesky Laura M LM Watson Steve P SP
The Journal of biological chemistry 20050929 47
The role of Rac family proteins in platelet spreading on matrix proteins under static and flow conditions has been investigated by using Rac-deficient platelets. Murine platelets form filopodia and undergo limited spreading on fibrinogen independent of Rac1 and Rac2. In the presence of thrombin, marked lamellipodia formation is observed on fibrinogen, which is abrogated in the absence of Rac1. However, Rac1 is not required for thrombin-induced aggregation or elevation of F-actin levels. Formatio ...[more]