Ontology highlight
ABSTRACT:
SUBMITTER: Yusuf MZ
PROVIDER: S-EPMC5514131 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Yusuf M Z MZ Raslan Z Z Atkinson L L Aburima A A Thomas S G SG Naseem K M KM Calaminus S D J SDJ
Scientific reports 20170717 1
Prostacyclin (PGI<sub>2</sub>) modulates platelet activation to regulate haemostasis. Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation. It was hypothesised that PGI<sub>2</sub> could reverse platelet spreading by actin cytoskeletal modulation, leading to reduced capability of platelet aggregates to withstand a high shear environment. Our data demonstrates that post-flow of PGI<sub>2</sub> over activated and spread platelets ...[more]