VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC139572 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
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VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus.
Chen Jing J Morita Yuji Y Huda M Nazmul MN Kuroda Teruo T Mizushima Tohru T Tsuchiya Tomofusa T
Journal of bacteriology 20020101 2
Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4',6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na(+)/drug transporter activity because the addition of tetraphenylphosphonium to Na(+)-loaded cells caused Na(+) efflux. ...[more]
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