Ontology highlight
ABSTRACT:
SUBMITTER: Rothbarth K
PROVIDER: S-EPMC140130 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Rothbarth Karsten K Stammer Hermann H Werner Dieter D
Cancer cell international 20020902 1
The C1D gene is expressed in a broad spectrum of mammalian cells and tissues but its product induces apoptotic cell death when exceeding a critical level. Critical levels are achieved in a fraction of cells by transient transfection with EGFP-tagged C1D expression constructs. However, transfected cells expressing sub-critical levels of C1D(EGFP) escape apoptotic cell death by activation of a proteasome-mediated rescue mechanism. Inhibition of the proteasome-dependent degradation of the C1D(EGFP) ...[more]