Ontology highlight
ABSTRACT:
SUBMITTER: Nardinocchi L
PROVIDER: S-EPMC3047137 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nardinocchi Lavinia L Puca Rosa R D'Orazi Gabriella G
Aging 20110101 1
Many human diseases are characterized by the development of tissue hypoxia. Hypoxia-inducible factor (HIF) is a transcription factor that regulates fundamental cellular processes in response to changes in oxygen concentration, such as angiogenesis, survival, and alterations in metabolism. The levels of HIF-1α subunit are increased in most solid tumors not only by low oxygen but also by growth factors and oncogenes and correlate with patient prognosis and treatment failure. The link between HIF-1 ...[more]