Ontology highlight
ABSTRACT:
SUBMITTER: Capili AD
PROVIDER: S-EPMC140198 | biostudies-literature | 2001 Jan
REPOSITORIES: biostudies-literature
Capili A D AD Schultz D C DC RauscherIII F J FJ Borden K L KL
The EMBO journal 20010101 1-2
Plant homeodomain (PHD) domains are found in >400 eukaryotic proteins, many of which are transcriptional regulators. Naturally occurring point mutations or deletions of this domain contribute to a variety of human diseases, including ATRX syndrome, myeloid leukemias and autoimmune dysfunction. Here we report the first structural characterization of a PHD domain. Our studies reveal that the PHD domain from KAP-1 corepressor binds zinc in a cross-brace topology between anti-parallel ss-strands rem ...[more]