Ontology highlight
ABSTRACT:
SUBMITTER: Johnston CA
PROVIDER: S-EPMC1405235 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Johnston Christopher A CA Willard Francis S FS Jezyk Mark R MR Fredericks Zoey Z Bodor Erik T ET Jones Miller B MB Blaesius Rainer R Watts Val J VJ Harden T Kendall TK Sondek John J Ramer J Kevin JK Siderovski David P DP
Structure (London, England : 1993) 20050701 7
Heterotrimeric G proteins are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive, GDP bound state and an active, GTP bound state. Under basal conditions, G proteins exist in the inactive, GDP bound state; thus, nucleotide exchange is crucial to the onset of signaling. Despite our understanding of G protein signaling pathways, the mechanism of nucleotide exchange remains ...[more]