Ontology highlight
ABSTRACT:
SUBMITTER: McBurney MW
PROVIDER: S-EPMC140671 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
McBurney Michael W MW Yang Xiaofeng X Jardine Karen K Hixon Mary M Boekelheide Kim K Webb John R JR Lansdorp Peter M PM Lemieux Madeleine M
Molecular and cellular biology 20030101 1
The yeast Sir2p protein has an essential role in maintaining telomeric and mating type genes in their transcriptionally inactive state. Mammalian cells have a very large proportion of their genome inactive and also contain seven genes that have regions of homology with the yeast sir2 gene. One of these mammalian genes, sir2alpha, is the presumptive mammalian homologue of the yeast sir2 gene. We set out to determine if sir2alpha plays a role in mammalian gene silencing by creating a strain of mic ...[more]