Ontology highlight
ABSTRACT:
SUBMITTER: Turhanen PA
PROVIDER: S-EPMC1408082 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20060224 1
A novel strategy for the synthesis of (1-alkanoyloxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives (1a-d) via (1-hydroxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives (2a-d), starting from alendronate has been developed with reasonable 51-77% overall yields. Intermediate products, (1-hydroxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives (2a-d), were prepared in water with reasonable to high yields (52-94%). ...[more]