Ontology highlight
ABSTRACT:
SUBMITTER: Brinkworth RI
PROVIDER: S-EPMC140887 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Brinkworth Ross I RI Breinl Robert A RA Kobe Bostjan B
Proceedings of the National Academy of Sciences of the United States of America 20021226 1
The large number of protein kinases makes it impractical to determine their specificities and substrates experimentally. Using the available crystal structures, molecular modeling, and sequence analyses of kinases and substrates, we developed a set of rules governing the binding of a heptapeptide substrate motif (surrounding the phosphorylation site) to the kinase and implemented these rules in a web-interfaced program for automated prediction of optimal substrate peptides, taking only the amino ...[more]