Ontology highlight
ABSTRACT:
SUBMITTER: Drexler I
PROVIDER: S-EPMC140931 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Drexler Ingo I Staib Caroline C Kastenmuller Wolfgang W Stevanović Stefan S Schmidt Burkhard B Lemonnier François A FA Rammensee Hans-Georg HG Busch Dirk H DH Bernhard Helga H Erfle Volker V Sutter Gerd G
Proceedings of the National Academy of Sciences of the United States of America 20021223 1
Despite worldwide eradication of naturally occurring variola virus, smallpox remains a potential threat to both civilian and military populations. New, safe smallpox vaccines are being developed, and there is an urgent need for methods to evaluate vaccine efficacy after immunization. Here we report the identification of an immunodominant HLA-A*0201-restricted epitope that is recognized by cytotoxic CD8(+) T cells and conserved among Orthopoxvirus species including variola virus. This finding has ...[more]