Ontology highlight
ABSTRACT:
SUBMITTER: Shitan N
PROVIDER: S-EPMC141068 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Shitan Nobukazu N Bazin Ingrid I Dan Kazuyuki K Obata Kazuaki K Kigawa Koji K Ueda Kazumitsu K Sato Fumihiko F Forestier Cyrille C Yazaki Kazufumi K
Proceedings of the National Academy of Sciences of the United States of America 20030110 2
Alkaloids comprise one of the largest groups of plant secondary metabolites. Berberine, a benzylisoquinoline alkaloid, is preferentially accumulated in the rhizome of Coptis japonica, a ranunculaceous plant, whereas gene expression for berberine biosynthetic enzymes has been observed specifically in root tissues, which suggests that berberine synthesized in the root is transported to the rhizome, where there is high accumulation. We recently isolated a cDNA encoding a multidrug-resistance protei ...[more]