Ontology highlight
ABSTRACT:
SUBMITTER: Rijpma SR
PROVIDER: S-EPMC4984424 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Rijpma Sanna R SR van der Velden Maarten M González-Pons Maria M Annoura Takeshi T van Schaijk Ben C L BC van Gemert Geert-Jan GJ van den Heuvel Jeroen J M W JJ Ramesar Jai J Chevalley-Maurel Severine S Ploemen Ivo H IH Khan Shahid M SM Franetich Jean-Francois JF Mazier Dominique D de Wilt Johannes H W JH Serrano Adelfa E AE Russel Frans G M FG Janse Chris J CJ Sauerwein Robert W RW Koenderink Jan B JB Franke-Fayard Blandine M BM
Cellular microbiology 20151110 3
Multidrug resistance-associated proteins (MRPs) belong to the C-family of ATP-binding cassette (ABC) transport proteins and are known to transport a variety of physiologically important compounds and to be involved in the extrusion of pharmaceuticals. Rodent malaria parasites encode a single ABC transporter subfamily C protein, whereas human parasites encode two: MRP1 and MRP2. Although associated with drug resistance, their biological function and substrates remain unknown. To elucidate the rol ...[more]