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TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity.

ABSTRACT: The natural history and pathogenic potential of the recently identified TT virus (TTV) are currently a matter of intensive investigation. In an attempt to shed some light on these issues, nasal and blood specimens of 1- to 24-month-old children hospitalized with a clinical diagnosis of acute respiratory disease (ARD) were examined for the presence, load, and genetic characteristics of TTV. The results have indicated that at least in young children, the respiratory tract not only represents a route by which abundant TTV can be shed into the environment but also may be a site of primary infection and continual replication. Although we found no compelling evidence that TTV was the direct cause of ARD in some of the children studied, the average loads of TTV were considerably higher in patients with bronchopneumonia (BP) than in those with milder ARD, raising interesting questions about the pathophysiological significance of TTV at this site. Furthermore, group 4 TTV was detected almost exclusively in children with BP.

SUBMITTER: Maggi F

PROVIDER: S-EPMC141071 | biostudies-literature | 2003 Feb

REPOSITORIES: biostudies-literature

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TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity.

Maggi Fabrizio F Pifferi Massimo M Fornai Claudia C Andreoli Elisabetta E Tempestini Elena E Vatteroni Marialinda M Presciuttini Silvano S Marchi Santino S Pietrobelli Angelo A Boner Attilio A Pistello Mauro M Bendinelli Mauro M

Journal of virology 20030201 4

The natural history and pathogenic potential of the recently identified TT virus (TTV) are currently a matter of intensive investigation. In an attempt to shed some light on these issues, nasal and blood specimens of 1- to 24-month-old children hospitalized with a clinical diagnosis of acute respiratory disease (ARD) were examined for the presence, load, and genetic characteristics of TTV. The results have indicated that at least in young children, the respiratory tract not only represents a rou ...[more]

PMID: 12551979

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Project description:To assess the concurrent and predictive validity of the Nasal Mucus Index (NMI), a novel measurement of acute respiratory infection (ARI) severity.ARI, including the common cold and influenza, imposes a great burden on individuals and society. Previous research has attempted to assess the severity of ARI with self-reported and laboratory-based measurements. Self-reported measurements may introduce bias. Laboratory-based metrics are often expensive. Therefore, there is a need for non-self-reported, affordable, and validated ARI severity tests.Participants (N = 719) with an ARI episode underwent nasal lavage on days 1 and 3. The samples were visually assessed for the amount of mucus present in the sample and were given a subsequent NMI score. Collected samples were further assessed for interleukin (IL) 8 values (in pg/mL) and polymorphonuclear neutrophils (PMN) per high-power field. The participants rated episode severity and nasal symptoms daily by using the validated Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21). A subset of nasal symptoms was used as an additional comparator. NMI scores were compared with same-day IL-8 level, PMN count, and WURSS-21 scores for concurrent validation purposes by using the Spearman ? as the index of correlation. NMI scores were correlated with overall episode severity measurements to assess predictive validity. Overall episode severity was measured as the WURSS-21 area under the curve, nasal symptoms area under the curve, and episode duration.The NMI score correlated significantly with the same-day IL-8 level (? = 0.443, p < 0.001), PMN count (? = 0.498, p < 0.001), WURSS-21 score (? = 0.098, p = 0.004), and nasal symptom score (? = 0.162, p < 0.001). No significant predictive correlations were found.Associations with inflammatory biomarkers and self-reported severity measurements provided evidence of concurrent validity for the novel NMI score. The NMI can be used in future research as a simple, inexpensive, non-self-reported indicator of ARI severity.

Dataset Information

TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity.

Publications

TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity.

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