Control of stochasticity in eukaryotic gene expression.
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ABSTRACT:
SUBMITTER: Raser JM
PROVIDER: S-EPMC1410811 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Publications
Control of stochasticity in eukaryotic gene expression.
Raser Jonathan M JM O'Shea Erin K EK
Science (New York, N.Y.) 20040527 5678
Noise, or random fluctuations, in gene expression may produce variability in cellular behavior. To measure the noise intrinsic to eukaryotic gene expression, we quantified the differences in expression of two alleles in a diploid cell. We found that such noise is gene-specific and not dependent on the regulatory pathway or absolute rate of expression. We propose a model in which the balance between promoter activation and transcription influences the variability in messenger RNA levels. To confi ...[more]
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