Ontology highlight
ABSTRACT:
SUBMITTER: Meredith M
PROVIDER: S-EPMC4632529 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Meredith Matthew M Zemmour David D Mathis Diane D Benoist Christophe C
Nature immunology 20150803 9
The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire's specificity, we performed single-cell RNA-seq and DNA-methylation analysis of Aire-sufficient and Aire-deficient medullary epithelial cells (mTECs). Each of Aire's target genes was induced in only a minority of mTECs, independently of DNA-methylation patterns, as small ...[more]