Ontology highlight
ABSTRACT:
SUBMITTER: Holler N
PROVIDER: S-EPMC141146 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Holler Nils N Tardivel Aubry A Kovacsovics-Bankowski Magdalena M Hertig Sylvie S Gaide Olivier O Martinon Fabio F Tinel Antoine A Deperthes David D Calderara Silvio S Schulthess Therese T Engel Jürgen J Schneider Pascal P Tschopp Jürg J
Molecular and cellular biology 20030201 4
The membrane-bound form of Fas ligand (FasL) signals apoptosis in target cells through engagement of the death receptor Fas, whereas the proteolytically processed, soluble form of FasL does not induce cell death. However, soluble FasL can be rendered active upon cross-linking. Since the minimal extent of oligomerization of FasL that exerts cytotoxicity is unknown, we engineered hexameric proteins containing two trimers of FasL within the same molecule. This was achieved by fusing FasL to the Fc ...[more]