Palmitoylation is required for efficient Fas cell death signaling.
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ABSTRACT:
SUBMITTER: Chakrabandhu K
PROVIDER: S-EPMC1782379 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Publications
Palmitoylation is required for efficient Fas cell death signaling.
Chakrabandhu Krittalak K Hérincs Zoltán Z Huault Sébastien S Dost Britta B Peng Ling L Conchonaud Fabien F Marguet Didier D He Hai-Tao HT Hueber Anne-Odile AO
The EMBO journal 20061207 1
Localization of the death receptor Fas to specialized membrane microdomains is crucial to Fas-mediated cell death signaling. Here, we report that the post-translational modification of Fas by palmitoylation at the membrane proximal cysteine residue in the cytoplasmic region is the targeting signal for Fas localization to lipid rafts, as demonstrated in both cell-free and living cell systems. Palmitoylation is required for the redistribution of Fas to actin cytoskeleton-linked rafts upon Fas stim ...[more]
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