A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks.
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ABSTRACT:
SUBMITTER: Conzelmann H
PROVIDER: S-EPMC1413560 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Publications
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks.
Conzelmann Holger H Saez-Rodriguez Julio J Sauter Thomas T Kholodenko Boris N BN Gilles Ernst D ED
BMC bioinformatics 20060123
<h4>Background</h4>Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial explosion of different states generated by feasible molecular species. The number of possible species grows exponentially with the number of different docking sites and can easily reach several millions. Models accounting for this combinatorial variety become impractical for many applications.<h4>Results</h4 ...[more]
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