Ontology highlight
ABSTRACT:
SUBMITTER: Pan G
PROVIDER: S-EPMC3557778 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Pan Guohui G Feng Yongqiang Y Ambegaonkar Abhijit A AA Sun Gongping G Huff Matthew M Rauskolb Cordelia C Irvine Kenneth D KD
Development (Cambridge, England) 20130114 4
The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways. Here we investigate the molecular basis for signal transduction downstream of Fat by creating targeted alterations within a genomic construct that contains the entire fat locus, and by monitoring and manipulating the membrane localization of the Fat pathway component Dachs. We establish that the human Fat homolog FAT4 lacks the ability to transduce Hippo signaling in Drosophila, but can transduc ...[more]