Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC1413670 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Lee Jongdae J Wu Christina C N CC Lee Ki Jeong KJ Chuang Tsung-Hsien TH Katakura Kyoko K Liu Yu-Tsueng YT Chan Michael M Tawatao Rommel R Chung Michelle M Shen Carol C Cottam Howard B HB Lai Michael M C MM Raz Eyal E Carson Dennis A DA
Proceedings of the National Academy of Sciences of the United States of America 20060130 6
IFN-alpha is used to suppress the replication of hepatitis C virus (HCV) in chronically infected patients with partial success. Here we present evidence showing that a ligand of Toll-like receptor 7 (TLR7) can induce anti-HCV immunity not only by IFN induction, but also through an IFN-independent mechanism. Human hepatocyte line Huh-7 carrying an HCV replicon expressed TLR7, and activation of the receptor induced several antiviral genes including IFN regulatory factor-7. Inhibitors of the enzyme ...[more]