Engineering a biospecific communication pathway between cells and electrodes.
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ABSTRACT:
SUBMITTER: Collier JH
PROVIDER: S-EPMC1413682 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Publications
Engineering a biospecific communication pathway between cells and electrodes.
Collier Joel H JH Mrksich Milan M
Proceedings of the National Academy of Sciences of the United States of America 20060206 7
Methods for transducing the cellular activities of mammalian cells into measurable electronic signals are important in many biotechnical applications, including biosensors, cell arrays, and other cell-based devices. This manuscript describes an approach for functionally integrating cellular activities and electrical processes in an underlying substrate. The cells are engineered with a cell-surface chimeric receptor that presents the nonmammalian enzyme cutinase. Action of this cell-surface cutin ...[more]
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