Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC1413715 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Liu Yingfang Y Manna Adhar C AC Pan Cheol-Ho CH Kriksunov Irina A IA Thiel Daniel J DJ Cheung Ambrose L AL Zhang Gongyi G
Proceedings of the National Academy of Sciences of the United States of America 20060202 7
The sarA locus in Staphylococcus aureus controls the expression of many virulence genes. The sarA regulatory molecule, SarA, is a 14.7-kDa protein (124 residues) that binds to the promoter region of target genes. Here we report the 2.6 A-resolution x-ray crystal structure of the dimeric winged helix SarA protein, which differs from the published SarA structure dramatically. In the crystal packing, multiple dimers of SarA form a scaffold, possibly via divalent cations. Mutations of individual res ...[more]