SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression.
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ABSTRACT:
SUBMITTER: Cheung AL
PROVIDER: S-EPMC2258893 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
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SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression.
Cheung Ambrose L AL Nishina Koren K Manna Adhar C AC
Journal of bacteriology 20080104 6
The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression. ...[more]
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