A microRNA expression signature of human solid tumors defines cancer gene targets.
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ABSTRACT:
SUBMITTER: Volinia S
PROVIDER: S-EPMC1413718 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
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A microRNA expression signature of human solid tumors defines cancer gene targets.
Volinia Stefano S Calin George A GA Liu Chang-Gong CG Ambs Stefan S Cimmino Amelia A Petrocca Fabio F Visone Rosa R Iorio Marilena M Roldo Claudia C Ferracin Manuela M Prueitt Robyn L RL Yanaihara Nozumu N Lanza Giovanni G Scarpa Aldo A Vecchione Andrea A Negrini Massimo M Harris Curtis C CC Croce Carlo M CM
Proceedings of the National Academy of Sciences of the United States of America 20060203 7
Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a, ...[more]
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