Ontology highlight
ABSTRACT:
SUBMITTER: Gagneux S
PROVIDER: S-EPMC1413851 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Gagneux Sebastien S DeRiemer Kathryn K Van Tran T Kato-Maeda Midori M de Jong Bouke C BC Narayanan Sujatha S Nicol Mark M Niemann Stefan S Kremer Kristin K Gutierrez M Cristina MC Hilty Markus M Hopewell Philip C PC Small Peter M PM
Proceedings of the National Academy of Sciences of the United States of America 20060213 8
Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated ...[more]