Ontology highlight
ABSTRACT:
SUBMITTER: Davis CA
PROVIDER: S-EPMC1413877 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Davis Carrie Anne CA Ares Manuel M
Proceedings of the National Academy of Sciences of the United States of America 20060216 9
Mutations in RRP6 result in the accumulation of aberrant polyadenylated transcripts from small nucleolar RNA genes. We exploited this observation to search for novel noncoding RNA genes in the yeast genome. When RNA from rrp6Delta yeast is compared with wild-type on whole-genome microarrays, numerous intergenic loci exhibit an increased mutant/wild type signal ratio. Among these loci, we found one encoding a new C/D box small nucleolar RNA, as well as a surprising number that gave rise to hetero ...[more]