Ontology highlight
ABSTRACT:
SUBMITTER: Gonzales-Zubiate FA
PROVIDER: S-EPMC5519375 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Gonzales-Zubiate Fernando A FA Okuda Ellen K EK Da Cunha Julia P C JPC Oliveira Carla Columbano CC
The Journal of biological chemistry 20170524 29
The exosome is a conserved multiprotein complex essential for RNA processing and degradation. The nuclear exosome is a key factor for pre-rRNA processing through the activity of its catalytic subunits, Rrp6 and Rrp44. In <i>Saccharomyces cerevisiae</i>, Rrp6 is exclusively nuclear and has been shown to interact with exosome cofactors. With the aim of analyzing proteins associated with the nuclear exosome, in this work, we purified the complex with Rrp6-TAP, identified the co-purified proteins by ...[more]