A low-cost open-source SNP genotyping platform for association mapping applications.
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ABSTRACT:
SUBMITTER: Macdonald SJ
PROVIDER: S-EPMC1414086 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
A low-cost open-source SNP genotyping platform for association mapping applications.
Macdonald Stuart J SJ Pastinen Tomi T Genissel Anne A Cornforth Theodore W TW Long Anthony D AD
Genome biology 20051202 12
Association mapping aimed at identifying DNA polymorphisms that contribute to variation in complex traits entails genotyping a large number of single-nucleotide polymorphisms (SNPs) in a very large panel of individuals. Few technologies, however, provide inexpensive high-throughput genotyping. Here, we present an efficient approach developed specifically for genotyping large fixed panels of diploid individuals. The cost-effective, open-source nature of our methodology may make it particularly at ...[more]
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