Ontology highlight
ABSTRACT:
SUBMITTER: Hovest MG
PROVIDER: S-EPMC1415309 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Hovest Miriam Grosse MG Brüggenolte Nicole N Hosseini Kijawasch Shah KS Krieg Thomas T Herrmann Gernot G
Molecular biology of the cell 20060125 4
Cellular senescence is a phenotype that is likely linked with aging. Recent concepts view different forms of senescence as permanently maintained DNA damage responses partially characterized by the presence of senescence-associated DNA damage foci at dysfunctional telomeres. Irradiation of primary human dermal fibroblasts with the photosensitizer 8-methoxypsoralen and ultraviolet A radiation (PUVA) induces senescence. In the present study, we demonstrate that senescence after PUVA depends on DNA ...[more]