Ontology highlight
ABSTRACT:
SUBMITTER: Hewitt G
PROVIDER: S-EPMC3292717 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Nature communications 20120228
Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been implicated in the ageing process. Telomere shortening has been shown to contribute to a persistent DNA damage response (DDR) during replicative senescence, the irreversible loss of division potential of somatic cells. Similarly, persistent DDR foci can be found in stress-induced senescence, although their nature is not understood. Here we show, using immuno-fluorescent in situ hybridization and ChIP, ...[more]