Ontology highlight
ABSTRACT:
SUBMITTER: Nde PN
PROVIDER: S-EPMC1418675 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Infection and immunity 20060301 3
It is thought that Trypanosoma cruzi, the protozoan that causes Chagas' disease, modulates the extracellular matrix network to facilitate infection of human cells. However, direct evidence to document this phenomenon is lacking. Here we show that the T. cruzi gp83 ligand, a cell surface trans-sialidase-like molecule that the parasite uses to attach to host cells, increases the level of laminin gamma-1 transcript and its expression in mammalian cells, leading to an increase in cellular infection. ...[more]